Beyond the alterations of the glucosidic metabolism, diabetes mellitus is considered a systemic metabolic disease because of the dysregulation of lipidic metabolism: insulin action on adipocytes and free fatty-acids levels are altered in these patients so the impairment of the lipid homeostasis and the vascular damage produced by the mechanisms already described increase the cardiovascular risk and death for cardiovascular causes [17]. The gene discussed is INS; the disease is Other metabolic disease.