Since the HMGB1 expression is closely associated with the cytokine-mediated nuclear factor kappa B (NF-kB) signalling pathways in sepsis [25], we examined its activated phospho-NF-κB p65 form (p-NF-κB p65) in the liver, kidney and heart, as well as the serum level of tumour necrosis factor alpha (TNFα) [26]. This evidence concerns the gene NFKB1 and Sepsis.