Katayama and colleagues reported that HSP-90 inhibition restored the sensitivity to FLT3 inhibitors in AML cell-lines with FLT3-ITD plus FLT3-TKD (e.g., N676K, F691L, D835V, and Y824C) which render resistance to FLT3 inhibition [111]. This evidence concerns the gene FLT3 and acute myeloid leukemia.