During embryogenesis, the activation of Akt/mTORC1 promotes the growth and development of the heart; however, in adults, the activation of this pathway leads to disruption of the autophagy process, and hyperactivity from hyperinsulinemia causes HF, while suppression of Akt signaling reduces the severity of hypertrophy and fibrosis of the myocardium and delays the development of HF [156]. This evidence concerns the gene AKT1 and Hyperinsulinemia.