At the same time, metformin can reduce the hyperglycemia-induced inhibition of the B1/AMPK/Akt pathway, activate GSK3-β, and prevent diabetes-induced cardiomyopathy [102], suggesting that, while some mechanisms of the protective effects of metformin are weakened under hyperglycemic conditions, others are characterized by high functionality. This evidence concerns the gene AKT1 and Hyperglycemia.