During embryogenesis, the activation of Akt/mTORC1 promotes the growth and development of the heart; however, in adults, the activation of this pathway leads to disruption of the autophagy process, and hyperactivity from hyperinsulinemia causes HF, while suppression of Akt signaling reduces the severity of hypertrophy and fibrosis of the myocardium and delays the development of HF [156]. The gene discussed is AKT1; the disease is hydrops fetalis.