Specifically, it has been demonstrated that miR-16 and miR-665 are down-regulated in OS cell lines (MG63, U2OS) and OS samples [77,81] and that both were able to suppress tumor cell progression and invasion through RAB23 modulation, a protein encoded by the RAB23 gene which is involved in tumor proliferation [81,101]. Here, RAB23 is linked to neoplasm.