When cell migration was analyzed using a transwell membrane, IL-17 and TNF-α stimulation also enhanced the migratory ability of RA FLS compared to unstimulated RA FLS controls, and inhibition of HIF-2α (33.0% less) and CD70 (29.4% less) attenuated cell migration (n = 5; Figure 5B,C). Here, EPAS1 is linked to rheumatoid arthritis.