These highly tumorigenic cancer stem cells are characterized by their ability to form melanospheres [25] and express receptors, cell adhesion molecules, or other stem cell markers, including ABCB5 [26], CD133 [27], CD20 [28], CD44 [29], CD144 [30], activated leukocyte cell adhesion molecule (ALCAM) [31], low affinity nerve growth factor receptor (LNGFR) [32], aldehyde dehydrogenase 1 (ALDH1) [33], Nestin [34], Tie1 [35], and JARID1B H3K4 demethylase [36]. The gene discussed is PROM1; the disease is cancer.