Previous studies highlighted a role for CD133 in AKT activation in liver and gastric cancer, as well as gliomas [60,61,62], where phosphorylation of CD133 Y828 facilitates its binding to the p85 subunit of phosphoinositide 3-kinase (PI3K), thereby phosphorylating and activating AKT [60]. Here, PROM1 is linked to central nervous system cancer.