BRAF and melanoma: Melanomagenesis is correlated with activating driver mutations primarily in codons V600 or K601 of BRAF (v-raf; murine sarcoma viral oncogene homolog B1; 50% of melanomas) or Q61 of NRAS (neuroblastoma RAS viral oncogene homolog; >20%), or LOF mutations in the tumor suppressor NF1 (neurofibromin 1; 10%).