ZNRF3 and obesity due to melanocortin 4 receptor deficiency: These included hypermethylated DMP annotated to the FGF9, MYOF, ZNRF3, ACSM3, AMN, APBB2, EGFL6, RBMS1, GNAQ, PTPRJ, and TOMM7 genes known to be important for osteogenesis and thermogenesis [50,51], adipogenesis [52], body fat distribution [53], fatty acid metabolism [54,55], obesity [56,57,58], glucose metabolism [59], type 2 diabetes and insulin signaling [60,61], respectively.