To the best of our knowledge, results from the present study demonstrate for the first time that TQ induces proliferation arrest and cell death in CRC by inhibiting PI3K-AKT, which in turn inhibits HK2 and hence glucose uptake, subsequently leading to the ATP debt and inhibiting molecular building blocks otherwise necessary for continued proliferation and growth of cancerous cells [56,92]. This evidence concerns the gene AKT1 and colorectal carcinoma.