Abcc6−/− mice developed spontaneously very mild calcifications at the time of the sacrifice (8 month-old animals) but CT-scan quantification of these cortical calcifications showed that calcium and calcium + vitamin D enriched diets significantly increased kidney arterial calcifications in Abcc6−/− mice (* p < 0.05 vs. Abcc6−/− control mice, Mann-Whitney test). The gene discussed is ABCC6; the disease is calcification.