Examples for myeloid disorders include overexpression of Dnmt1 in AML and myelodysplastic syndromes [74], inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders [75], and downregulation of the tumor-suppressor mRNA-495 in MLL-rearranged AML [76]. The gene discussed is PRDM9; the disease is acute myeloid leukemia.