ANGPT2 and cancer: Hypoxia-inducible factor 1α (HIF-1α), but also HIF-2α, angiopoietin-2 (Ang-2), fibroblast growth factor (FGF), and insulin-like growth factors (IGF) are involved in cancer progression (vimentin mediated EMT stimulation) and angiogenesis stimulation (VEGF upregulation) under hypoxia condition [79].