TGFB1 and neoplasm: The recruitment of immune cells, and their localization by the tumor side, are regulated by immunosuppressive molecules from cancer cells (prostaglandin, histamine, epinephrin, indoleamine 2,3-dioxygenase, arginase, TNF-α, TGF-β, and IL-10) under metabolomic conditions in TME (hypoxia).