The plausibility of direct infection of the kidney by SARS-CoV-2 stems, in part, from the fact that the receptors for cellular viral entry, including angiotensin-converting enzyme-2 (ACE2), are highly expressed in the proximal tubule, particularly in the apical brush border of the proximal tubule [109,110,111,112,113,114]. This evidence concerns the gene ACE2 and pyelonephritis.