To our knowledge, this study is the first in which it is demonstrated a remarkable decline in the expression of all five examined transporters, i.e., CD36, FABPpm, FATP1, 4, and 6, after 2-week CBD treatment under conditions of high-fat diet-induced obesity in Wistar rats (Scheme 1). The gene discussed is CD36; the disease is obesity due to melanocortin 4 receptor deficiency.