The surface expression of CCR5 was significantly lower in SSc–ILD patients compared to SSc without ILD and HC in the total monocytes (MFI 2.7 (1.7) vs. 3.7 (1.4), p = 0.0277 and vs. 3.5 (2.1), p = 0.287), classical (MFI 3.2 (1.9) vs. 4.0 (1.5), p = 0.0237; and 3.7 (2.2), p = 0.0237), and intermediate subset (MFI 3.5 (2.5) vs. 5.9 (2.5), p = 0.0022; and 6.2 (2.4), p = 0.0017, respectively) (Figure 4). The gene discussed is CCR5; the disease is interstitial lung disease.