There was a significant decrease in CCR5 surface expression in the SSc intermediate monocytes compared to HC (MFI 5.5 (2.6) vs. 6.2 (2.4), p = 0.035) and a decrease in CD11b surface expression in the SSc total monocytes (MFI 26.1 (44.7) vs. 45.3 (36.2), p = 0.065), classical (MFI 31.9 (45.2) vs. 47.5 (36.4), p = 0.067), and non-classical subsets (MFI 5.4 (3.8) vs. 7.7 (9.7), p = 0.053) compared to HC. This evidence concerns the gene ITGAM and systemic sclerosis.