Nanoparticles coated with membranes of cancer cells, which naturally present their own antigens via MHC-I, engineered to express both CD80, a costimulatory signal, and ovalbumin (OVA), an antigen, can act as an artificial APCs and promote the activation of the cognate T cells as compared with that of ones coated with wild-type cancer cell membranes [13]. This evidence concerns the gene CD80 and cancer.