In the intraperitoneal metastatic microenvironment, CAFs govern the metastatic cascade, including the adhesion, proliferation, invasion, and colonization of metastatic sites via increasing production of several molecules (CXCL12, IL-6, VEGFA, TGF-α, and β, FGF-1) within the tumor microenvironment [21,22,23,24]. The gene discussed is CXCL12; the disease is neoplasm.