In concordance with the result, another dataset of PCa tissue samples from patients with PCa (n = 150), including 19 patients with metastatic PCa (GSE21032), also showed that patients with GS ≥ 8 had significantly lower mRNA levels of S1PR2 and LDLR in prostate tissues than those with GS ≤ 7 (p = 0.013, p < 0.001, respectively, Figure 5F). Here, S1PR2 is linked to posterior cortical atrophy.