To evaluate the effect of body mass index (BMI) on S1PR2 and LDLR mRNA expression in patients with PCa, the database using paraffin-embedded tumor samples after radical prostatectomy (n = 50, GSE13512) showed that patients with higher BMI had a significantly lower S1PR2 RNA levels than those with lower BMI (p = 0.047, Figure 5H), whereas no significant relationship was found between the LDLR expression and BMI (p = 0.289, Figure 5H). This evidence concerns the gene S1PR2 and posterior cortical atrophy.