Regarding the database of primary PCa tissue samples from patients with PCa following radical prostatectomy (n = 203, GSE70770), patients with a higher Gleason score (≥8) had significantly lower mRNA expressions of S1PR2 and LDLR than patients with GS ≤ 7 (p = 0.021, p < 0.001, respectively, Figure 5E). This evidence concerns the gene LDLR and posterior cortical atrophy.