Given that S1PR2 and LDLR were previously reported to be associated with gut microbial conditions [25,26], the relationship between the gene expression of the two genes and the clinical outcomes of patients with PCa were explored using NCBI Gene Expression Omnibus (GEO) datasets to understand the roles of S1PR2 and LDLR expressions in human PCa. The gene discussed is S1PR2; the disease is posterior cortical atrophy.