One particular SNP, rs1466785, located 5′ to the hNEIL2 coding part, is strongly associated with increased cancer risk in BRCA2 mutation carriers [19] and decreased blood triglyceride levels [20], while a nearby rs804271 polymorphism increases gene expression, increases DNA damage at telomeres in BRCA1 or BRCA2 mutation carriers, and was classified as a cancer risk modifier [21]. The gene discussed is BRCA2; the disease is cancer.