In particular, the expression of NTSR3/sortilin was detected in adipocytes and myocytes; in these cells, the hyper-activation of the NT/NTSR3 axis downregulated the translocation of the insulin-sensitive glucose transporter 4 (GLUT4) [89,90], thus providing further molecular basis for the development of insulin resistance associated with elevated pro-NT levels. Here, NTS is linked to Insulin resistance.