We observed a distinct down-regulation of IQGAP1and LGALS3 in our SILAC analysis, but astonishingly, In contrast to our findings, IQGAP1and LGALS3was markedly up-regulated in HBV-positive patients and positively correlated to poor prognosis of HBV-associated HCC patients [46,47,48]. Here, LGALS3 is linked to hepatocellular carcinoma.