SIRT1 and colorectal carcinoma: Furthermore, the observed effects of this miR in cell migration could also be explained by the fact that miR-199b also regulates additional targets such as JAG1 [31,32,38], DDR1 [35,36,38] or SIRT1 [42], which have been reported to be involved in the regulation of cell migration and invasion in CRC, as well as in other tumor types.