Furthermore, the observed effects of this miR in cell migration could also be explained by the fact that miR-199b also regulates additional targets such as JAG1 [31,32,38], DDR1 [35,36,38] or SIRT1 [42], which have been reported to be involved in the regulation of cell migration and invasion in CRC, as well as in other tumor types. This evidence concerns the gene SIRT1 and neoplasm.