ADRB3 and heart failure: In this study, we evaluated the effects of chronic administration of the selective AT1 receptor blocker losartan, the β3AR agonist mirabegron, and their combination on LV morphology, function, and molecular markers of cardiac fibrosis, remodeling, heart failure, inflammation, and nitro-oxidative stress in a rat model of DOXO-induced chronic cardiotoxicity (Figure 8).