CD8A and neoplasm: In contrast, in studies on triple-negative breast cancer [113], colorectal cancer [114], clear cell renal cell carcinoma [115], gastric cancer [116] and pancreatic ductal adenocarcinoma [117] (Table 1), no such association is shown, which may be related to the initiation of an antitumor immune response resulting in tumor infiltration by tumor-infiltrating lymphocytes (TILs), in particular CD8+ cytotoxic lymphocytes [113].