Both miR-17 and miR-20a share an identical seed sequence and, therefore, share many similar confirmed targets in CRC (BCL2L11, CDKN1A, PTEN, TGFBR2, and VEGFA) [143,165], while also having individualized targets as seen with miR-17 and RBL2 and miR-20a with BID and SMAD4 [78,166], stressing a non-seed sequence-based influence. The gene discussed is PTEN; the disease is colorectal carcinoma.