PTEN and neoplasm: Similar to miR-21 and miR-19a, miR-92a activates the PI3K/AKT cell cycle pathway via PTEN inhibition, as well as activating Wnt/ß-catenin signaling, promoting carcinogenic development [59,161,162] and downregulating the tumor suppressors RECK and KLF4 [163,164].