AKT1 and neoplasm: The canonical pathway for miR-21-induced oncogenesis is through to be the direct repression of various well-known tumor suppressor genes, including PTEN [120,129] and PDCD4 [130,131], which activate cyclin-dependent kinases, c-MYC, and PI3K/AKT/mTOR pathways, which results in an increased invasion and metastasis [10,125,132,133,134].