Additionally, strong evidence suggests the noncanonical binding of miRNAs occurs with functional effects as seen with miR-21 binding/activating Toll-like receptor proteins (TLR8) [35], as well as binding the lncRNA GAS5 [36], with both leading to pro-inflammatory signaling cascades, which are also found in CRC. This evidence concerns the gene GAS5 and colorectal carcinoma.