Similar to miR-21, miR-19a directly inhibits the tumor suppressor PTEN [151,152], as well as TIA1 [153], and can be predictive of the effectiveness of chemotherapeutic interventions on CRC [72,152], all while isolated miR-19a seemingly inhibits CRC angiogenesis via KRAS reduction [154]. Here, PTEN is linked to colorectal carcinoma.