OI type V is caused by the single recurrent mutation (c.-14C>T) in the 5’ untranslated region of BRIL, leading to the creation of an in-frame ATG with the addition of 5 amino acids (MALEP) at the N-terminus of BRIL [15,16]. The gene discussed is IFITM5; the disease is osteogenesis imperfecta type 5.