Flow cytometric analysis of E-cadherin and apoptosis in MDA-MB-231 and 4T1 metastatic breast cancer cell line was undertaken after treatment with Cur, Pacli, CP, Au-C, Au-P, and Au-CP, and it was observed that combination treatments were exerting better cell apoptosis and inhibiting the metastatic E-cadherin pathway in both breast cancer cell lines in comparison with either substance alone in cancer cell lines. The gene discussed is CDH1; the disease is breast carcinoma.