NFKB1 and breast cancer: In addition, the mechanism of CUR inhibitory effect on NF-ĸB pathway has been suggested to operate through suppression of NF-κB expression and its translocation to the nucleus, inhibition of IKK activity, and IκB degradation, which result in diminishing its target expression, cyclin D1, IAP, surviving, EMT markers, etc., in breast cancer studies [27,28,29,30].