Consistent with this finding, MMP-10 protein is not only induced significantly in adriamycin (ADR) mice in a time-dependent fashion, but is also upregulated in other proteinuric CKD models, such as diabetic db/db mice, remnant kidney model after 5/6 nephrectomy (5/6NX), Alport mice, CD151 null mice and α-actinin-4 knockout mice, which are a Alport syndrome model and a model of FSGS, respectively [7,33,50,55]. The gene discussed is MMP10; the disease is chronic kidney disease.