Using human melanoma and breast cancer cell lines implanted in mice, Das and colleagues found that CCL1 expression on lymph node sinuses controls initial tumor entry into the lymph node; neutralization of CCR8, the receptor for CCL1, led to the sequestration of tumor cells at the junction of the collecting lymphatic vessel and the lymph node subcapsular sinus [68]. Here, CCL1 is linked to breast carcinoma.