VEGF-C mediated potentiation of adoptive T-cell therapy was dependent on CCR7-mediated attraction of naïve T cells to the local TME; this was shown to occur through VEGF-C-induced CCL21 upregulation in tumor lymphatics because CCR7 blockade reversed the potentiating effects of VEGF-C [97]. This evidence concerns the gene CCL21 and neoplasm.