Thus, in a neurodevelopmental model of schizophrenia, e.g., in rats with a neonatal ibotenic lesion of the ventral HIP [49,50] or in rats exposed to the MAM toxin during embryogenesis [19], decreases in BDNF mRNA and its protein were observed in both the PFC and HIP in adulthood [51,52,53]. Here, BDNF is linked to schizophrenia.