Chronic AD lesions display a complex inflammation signature (Th1/Th2/Th17/Th22/Th9) associated with keratinocyte (KC) hyperproliferation and altered terminal differentiation as well as skin superinfection, especially with Staphylococcus bacteria [9,19,29,30,31,32,33,34,35,36,37]. Here, CALCA is linked to Alzheimer disease.