Neurogenic inflammation induced by dural sensory nerve stimulation and consequent release of proinflammatory neuropeptides such as calcitonin-gene related peptide (CGRP), tachykinins and PACAP, is an important component of migraine [21] It consists of meningeal vasodilatation, plasma protein extravasation (oedema formation) and activation of inflammatory cells including mast cells [22], which in turn also release inflammatory mediators i.e., cytokines and peptides, such as PACAP [23]. This evidence concerns the gene ADCYAP1 and migraine disorder.