In this study, there was no difference in the expression of epidermal proteins KRT14 and KRT10 in AD-HSE stimulated with IL-4/IL-13 for 3 days, whereas AD-HSE stimulated for 7 and 14 days showed reduced expression of KRT14 and KRT10, which was attributed to reduced KC differentiation. The gene discussed is IL4; the disease is Alzheimer disease.