Emonts et al. [46] showed that in the Caucasian population (376 RA patients vs. 463 healthy subjects), IL-8 rs2227306 gene polymorphism was related to the increased RA susceptibility, but the CC genotype of IL-8 rs2227306 was associated with early onset of RA diagnosis compared to the CT and TT genotypes [46]. Here, CXCL8 is linked to rheumatoid arthritis.