NR3C2 and atrial fibrillation: As regards to patients with PA, in a large-scale prospective observational cohort study with an 11.8-year median follow-up, Rossi et al. reported a significantly worse AF-free survival in medically treated PA patients as compared with EH patients, whereas adrenalectomy was associated with AF-free survival similar to that of optimally treated EH patients, thus suggesting that removing the cause of aldosterone excess is better than controlling the MR-mediated effects of aldosterone [27].