However, Lavall et al. reported that 11â-hydroxysteroid dehydrogenase type 2, an enzyme which converts cortisol to inactive metabolites allowing aldosterone binding to the MR, is upregulated in the left atrial myocardium of patients with AF, thereby suggesting that MR activation in this setting is mainly due to aldosterone [32]. Here, NR3C2 is linked to atrial fibrillation.