In total, five Reactome pathways were significantly enriched (PFDR < 0.05 and E > 1) in hsa-miR-215-5p and/or hsa-miR-1246 target genes, three out of which were responsible for “Signaling by WNT in cancer” (both miRNAs: PFDR = 2.12 × 10−3; hsa-miR-215-5p: PFDR = 0.015), “Degradation of beta-catenin by the destruction complex” (both miRNAs: PFDR = 2.72 × 10−5), and “Binding of TCF/LEF:CTNNB1 to target gene promoters” (hsa-miR-1246: PFDR = 0.024). This evidence concerns the gene CTNNB1 and cancer.