Although the origin of hsa-miR-1246 remains controversial due to sequence overlap with the central region of the RNU2-1 transcript [31], this molecule has been repeatedly reported to function as an oncogene and to promote tumor angiogenesis, growth, migration, invasion, metastasis, and stemness in various cancer types, including CRC [29,31,32,33,34]. This evidence concerns the gene RNU2-1 and colorectal carcinoma.