However, in adipose tissue analyzed pre- and posttreatment, several adipose tissue cytokines and chemokines associated with obesity, including IL-6, MCP-1, C–C motif chemokine ligand 2 (CCL2), interleukin 7R and CX3CL1, were markedly less expressed. The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.