Accordingly, it has been clarified that CERT and CERTL (also known as GPBPΔ26 and GPBP, respectively) participate in various events and functions in mammalian cells, including polyploid cancer cell death [95], EGF receptor signaling [96], lipotoxicity and glucolipotoxicity in islet β-cells [97,98], muscle insulin signaling [99], myofibril formation [100], integrity of glomerular basement membrane [101], cytotoxic autophagy [102], mitochondrial maintenance [103], and senescence [104]. This evidence concerns the gene CERT1 and cancer.