Based on the results, apolipoprotein A-IV (APOA4), apolipoprotein C-III, IGFBP2 and tissue inhibitor of metalloproteinase 1 (TIMP1) were found significantly altered in the serum of PDAC patients (stage I–IV) compared to those with pancreatitis as well as healthy controls. This evidence concerns the gene APOA4 and pancreatitis.