AGER and early-onset autosomal dominant Alzheimer disease: It has been previously reported that RAGE deficiency (i.e., absence of mRAGE and sRAGE) and treatment with purified recombinant sRAGE in mice lead to a protective effect in organs under various pathological conditions, such as acute lung injury, diabetic atherosclerosis, kidney diseases, Alzheimer’s disease, and septic shock [2,5,19,55].