VEGFA and Kaposi's sarcoma: This is because IC induce production and release of angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF), which are highly expressed in all forms of KS and synergize in promoting angiogenesis, matrix-metalloproteases expression and activation, vascular permeability, and edema [13,37,38,39,40,41,42,43] as observed in human KS lesions [1,15].