Specifically, IC such as interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin (IL)-1, and IL-6 are increased in lesions and blood of KS patients and in individuals at risk of KS even before lesion development [6,7,8,9,10,11]. This evidence concerns the gene IL1B and Kaposi's sarcoma.