In addition to this, Tat enhances HHV-8 infectivity in endothelial cells, promotes the recruitment of HHV-8-infected circulating KS cells from blood, and potentiates the angiogenic and oncogenic activity of HHV-8 proteins such as vGPCR, vIL-6, K1, and kaposin A through the modulation of the PI3K/AKT pathway [15,27,28,29,30,31,32]. This evidence concerns the gene TAT and Kaposi's sarcoma.