It is interesting to note that all of them were identified in all the zones analyzed, i.e., both in the tumor (CORE and A+) and in the healthy (A−) zone of ND- and R-GBM pools, with the exception of complement factor H-related protein 1, not identified in ND-GBM, and of inter-alpha-trypsin inhibitor heavy chain H4 protein, that in ND-GBM was not identified in the tumor core. The gene discussed is ITIH4; the disease is glioblastoma.