A study by Zhuang et al. (2018) reported that administration of quercetin isolated from Edgeworthia gardneri at a dose of 0.5 g/kg quercetin per day for 4 weeks in db/db mice with type 2 diabetes mellitus (T2DM) could induce insulin secretion at a concentration of 0.10 mol/L, inhibit palmitate-induced pancreatic cell apoptosis and ameliorate mitochondrial dysfunction [61]. This evidence concerns the gene INS and type 2 diabetes mellitus.