TRIB3 and colorectal cancer: In addition, TRIB3 activated the Wnt-β-catenin signaling pathway via the C-terminal and N-terminal regions of the kinase-like domain in TRIB3, directly binding to β-catenin in colorectal cancer [32], indicating that activation of Wnt/β-catenin signaling by SALL4 may require TRIB3 expression.