For one thing, SALL4 is an underlying biomarker that activates signaling pathways and oncoproteins that promote tumor progression including Wnt/β-catenin (Figure 1), PI3K/AKT (Figure 2), Notch signaling pathway (Figure 3), and OXPHOS (Figure 7), as well as Bcl-2, TNF-α, and IFN-γ (Figure 5). This evidence concerns the gene TNF and neoplasm.