BMI1 and acute myeloid leukemia: SALL4 knockdown in AML cells resulted in upregulation of apoptotic genes, including CARD9, CARD11, TNF, ATF3, TP53, PTEN, and LTA, but downregulation of antiapoptotic genes, such as Bmi-1, Bcl-2, DAD1, BIRC4, BIRC7, and TEGT [80].