SALL4 knockdown also induced cell cycle arrest, enhanced early apoptosis, and inhibited invasion in glioma, which was associated with a markedly low expression of the core transcription factors, including POU class 5 homeobox 1; SOX2; and Nanog homeobox in glioblastoma multiforme (GBM), a subtype of glioma [210]. The gene discussed is SOX2; the disease is central nervous system cancer.