Consistent with these observations, MYC expression was reduced also in Raji cells, another human Burkitt’s lymphoma cell line, and in primary B-cell lymphoma extracts from Ibtk−/−Eμ-myc mice, compared to Ibtk+/+Eμ-myc tumorigenic mice (Figure 1E–H). Here, IBTK is linked to B-cell non-Hodgkin lymphoma.