CRY1 and central nervous system cancer: Moreover, both Madden et al. 2014 [26] (with a sample 10 times larger than that of Luo et al. 2012) and Wang et al. 2021 [27] (using data from three different databases) analyzed the expression of circadian genes in glioma tissue compared to healthy tissue and conclude that cry1 is overexpressed in glioma tissue.