AIF1 and Parkinson disease: To investigate whether the neuroinflammation accompanied by glial activation occurs in PD mice, glial fibrillary acidic protein (GFAP) and ionized calcium binding adaptor molecule-1 (Iba-1), the markers of astrogliosis and microgliosis, were detected by double IF staining for TH and GFAP or Iba-1, respectively.