Indeed, cellular response has been detected against alpha-fetoprotein (AFP), glypican-3 (GPC-3), melanoma-associated genes (MAGE)-1, 3, and 10, synovial sarcoma X (SSX)-2, and New York-esophageal squamous cell carcinoma-1 (NY-ESO-1) in blood, as well as in the tumors of HCC patients [31,32,33,34]. This evidence concerns the gene AFP and hepatocellular carcinoma.