This tumor class is subdivided into the “Wnt-TGF-β subclass”, characterized by activation of Wnt and TGF-β pathways, usually associated with an exhausted immune response [11], and the “progenitor subclass”, with upregulated expression of hepatic progenitor markers and IGF1R and AKT pathways [9]. Here, TGFB1 is linked to neoplasm.