SERPINE1 and Alzheimer disease: They found that several proteins associated with cellular senescence and adhesion, including Serpine1 (also called PAI-1), a serine protease inhibitor and cell senescence marker [51,52,53,54,55,56,57], were significantly increased in B3 microvessels from AD patients, compared with that from the controls after adjusting for sex and cerebrovascular pathology [58].